Although the cause has not been fully uncovered, it is thought that breastfed babies are less likely than formula-fed newborns to experience allergic diseases including eczema and food allergies. According to a recent study from Penn State College of Medicine, tiny chemicals contained in the breast milk of the majority of people may lessen the chance that newborns would acquire allergic diseases such atopic dermatitis and food allergies. The discovery, according to the researchers, may lead to initiatives for women to help reduce the likelihood that their children would have allergies, such as encouraging and supporting breastfeeding or nutritional and activity therapies.

About one-third of children have atopic diseases such food allergies, asthma, and a skin condition called atopic dermatitis as a result of improper immune system response to environmental exposures. According to Dr. Steven Hicks, an associate professor of paediatrics and a paediatrician at Penn State Health Children's Hospital, infants who continue to breastfeed through the age of three months may have a lower risk for these diseases, however the biology underlying this is yet unclear.

The link between the environment, biology, and children's growth and neurodevelopment is the main subject of Hicks' research. His earlier research has shown how micro ribonucleic acids (miRNAs), tiny molecules that may control gene expression throughout the body, can be utilised to identify specific medical problems like autism or concussion. Human breast milk contains up to 1,000 different types of miRNAs, and the composition varies depending on the maternal traits like weight, food, and genetics "explained Hicks. "Based on recent studies linking these miRNAs to particular allergy disorders, we proposed that four of these miRNAs might have a protective effect against baby allergies.

From birth to 12 months old, 163 moms who intended to breastfeed for at least four months were monitored by the researchers. They monitored the duration of each infant's breastfeeding as well as the miRNA content of each mother's breast milk throughout lactation (0, 4 and 16 weeks). Based on reported nursing habits and the concentration of particular miRNAs in mothers' milk samples, the researchers determined the quantity of particular miRNAs that newborns absorbed. Throughout the study, the researchers checked the infants for wheezing, food allergies, and atopic dermatitis.

Hicks believes that the results of this study could result in fresh approaches to preventing allergic reactions in young children. Future studies will concentrate on verifying these results, clarifying the mechanisms by which miR-375 protects allergies, and investigating methods to raise the concentration of miR-375 in breast milk from mothers. Hicks noted that if additional study is done, miR-375—which is now absent from formula—might one day be added to it to assist solve the issue that formula-fed infants are more prone to develop atopic diseases.

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Journal Coordinator
Journal of Molecular Oncology Research